HCID 18340695, 화합물 → Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

HRID 1913212노트

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HRID 1913212 반응식
[C:1]([O:5][C:6](=[O:19])[CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]>CCOC(C)=O>[C:1]([O:5][C:6](=[O:19])[CH2:7][CH:8]1[CH2:9][CH2:10][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13]1)([CH3:3])([CH3:4])[CH3:2]

참가 물질

3

반응물 1

HCID 18340695HCID 18340695, 화합물

생성물 1

HCID 66613615Ethyl 4-(2-tert-butoxy-2-oxoethyl)cyclohexanecarboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a 250 mL round-bottom flask was charged ethyl 4-(2-tert-butoxy-2-oxoethylidene)cyclohexanecarboxylate (Int-4a, 5.38 g, 19.90 mmol) followed by EtOAc (100 mL). The flask was flushed with argon and then 5% palladium on carbon was added. The flask was sealed and degassed under vacuum. H2 (g) was added in a balloon and the reaction was allowed to stir 18 hours under hydrogen atmosphere. After 18 hours, the reaction mixture was filtered through celite. The solvent was removed in vacuo and the resulting oil was taken on without further purification.

후처리

  1. customThe flask was flushed with argon
  2. addition5% palladium on carbon was added
  3. customThe flask was sealed
  4. customdegassed under vacuum
  5. additionH2 (g) was added in a balloon
  6. waitAfter 18 hours
  7. filtrationthe reaction mixture was filtered through celite
  8. customThe solvent was removed in vacuo
  9. customthe resulting oil was taken on without further purification

출처 및 근거

ORD 기록
ord-6fa096afaeb1418ea822e43253b338f9
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609675B2

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