HCID 66879199, 화합물 → HCID 178468818, 화합물

HRID 1913215노트

반응식

HRID 1913215 반응식
C(O[C:4](=[O:20])[CH2:5][C:6](=O)[CH2:7][CH:8]1[CH2:13][CH2:12][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)C.[NH2:21][C:22]1[CH:26]=[CH:25][NH:24][N:23]=1>CCO>[OH:20][C:4]1[N:23]2[N:24]=[CH:25][CH:26]=[C:22]2[N:21]=[C:6]([CH2:7][CH:8]2[CH2:9][CH2:10][CH:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13]2)[CH:5]=1

참가 물질

4

반응물 2

HCID 66879199HCID 66879199, 화합물HCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178468818HCID 178468818, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

To a 50 mL round-bottom flask containing ethyl 4-(4-ethoxy-2,4-dioxobutyl)cyclohexanecarboxylate (Int-4e, 2.33 g, 8.19 mmol) was added 3-amino-1H-pyrazole (681 mg, 8.19 mmol). The flask was heated via heat gun to ensure mixing of the oils, and then the reaction was shaken at 100° C. for 18 hours. After 18 hours, the resulting solid was taken up in EtOH and then the solvent was removed in vacuo to dry product. The product was then pumped dry on high vacuum overnight to further dry the product. The compound was taken on without further purification.

후처리

  1. temperatureThe flask was heated
  2. temperaturevia heat gun
  3. additionto ensure mixing of the oils
  4. waitAfter 18 hours
  5. customthe solvent was removed in vacuo to dry product
  6. customThe product was then pumped dry on high vacuum overnight
  7. customto further dry the product
  8. customThe compound was taken on without further purification

출처 및 근거

ORD 기록
ord-86c4127d0e6a40f7922627b45bcfc556
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609675B2

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