Sulfuryl chloride → [(Chlorocarbonyl)oxy]methyl 2-methylpropanoate

반응식

[CH3:1][CH:2]([CH3:13])[C:3]([O:5][CH2:6][O:7][C:8](SCC)=[O:9])=[O:4].S(Cl)([Cl:17])(=O)=O>>[CH3:1][CH:2]([CH3:13])[C:3]([O:5][CH2:6][O:7][C:8]([Cl:17])=[O:9])=[O:4]

참가 물질

반응물 2

HCID 24648Sulfuryl chloride

HCID 85885666Isobutyric acid ethylsulfanylcarbonyloxymethyl ester

생성물 1

HCID 19067202[(Chlorocarbonyl)oxy]methyl 2-methylpropanoate

실험 절차

The compound (400 mg) obtained in Step 2 of this Example was cooled to −30° C. Sulfuryl chloride (159 μL) was added thereto, and the mixture was stirred at the same temperature for 20 minutes. The mixture was in turn stirred for 20 minutes in an ice bath and further at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and the residue was dried to obtain a crude product of the title compound.

후처리

customwas cooled to −30° C
stirringstirred for 20 minutes in an ice bath and further at room temperature for 1 hour
distillationThe solvent was distilled off under reduced pressure
customthe residue was dried

출처 및 근거

ORD 기록: ord-c58152f509424c4793a0f1ef193ef4f6
출처 데이터셋: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08609710B2

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