2-Chloro-6-nitro-4-(trifluoromethyl)phenol → 2-Amino-6-chloro-4-(trifluoromethyl)phenol
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([N+:12]([O-])=O)[C:3]=1[OH:15].[H][H]>[Pd].C(OCC)(=O)C>[NH2:12][C:4]1[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=[C:2]([Cl:1])[C:3]=1[OH:15]참가 물질
5
실험 절차
A mixture of 5.01 g of a mixture containing 2-chloro-4-(trifluoromethyl)-6-nitrophenol, 15 ml of ethyl acetate and 1.0 g of 5% palladium on carbon was stirred under about one atmosphere of hydrogen at room temperature for 15 hours. The mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 2.78 g of 2-amino-6-chloro-4-(trifluoromethyl)phenol.
후처리
- filtrationThe mixture was filtered through Celite™
- concentrationThe filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-eab55884839248cea1593bfc26bba703
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08609705B2
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