홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → HCID 25164161, 화합물

HRID 1913804
노트
인쇄 미리보기

반응식

HRID 1913804 반응식
[O:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)CC)C.[N:48]1([CH2:53][C:54]2[CH:55]=[C:56]3[C:61](=[CH:62][CH:63]=2)[CH2:60][C@@H:59]([NH2:64])[CH2:58][CH2:57]3)[CH2:52][CH2:51][CH2:50][CH2:49]1>CN1C(=O)CCC1.C(OCC)(=O)C>[N:48]1([CH2:53][C:54]2[CH:55]=[C:56]3[C:61](=[CH:62][CH:63]=2)[CH2:60][C@@H:59]([NH:64][C:12](=[O:14])[C:11]2[CH:10]=[CH:9][C:8]([O:7][CH2:6][C@@H:2]4[CH2:3][CH2:4][CH2:5][O:1]4)=[CH:16][CH:15]=2)[CH2:58][CH2:57]3)[CH2:52][CH2:51][CH2:50][CH2:49]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 2402152HCID 2402152, 화합물HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 66663464(S)-6-Pyrrolidin-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-ylamine

생성물 1

HCID 25164161HCID 25164161, 화합물

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매
HCID 13387N-methyl-2-pyrrolidone용매2회

실험 절차

To a solution of 4-[(S)-1-(TETRAHYDROFURAN-2-YL)METHOXY]BENZOIC ACID (3.38 g) in NMP (30 ml) were added HATU (O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N′,N′-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; 5.78 g) and then triethylamine (2.12 ml). A solution of (S)-6-pyrrolidin-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-ylamine (3.5 g) in NMP (20 ml) was added dropwise. After 12 hours, the reaction mixture was diluted with ethyl acetate, washed with saturated sodium carbonate solution and concentrated. The residue was purified by chromatography on silica gel (eluent: 10:1 DCM/MeOH). The product was thus obtained with the molecular weight of 434.58 (C27H34N2O3); MS (ESI): 435 (M+H+).

후처리

  1. washwashed with saturated sodium carbonate solution
  2. concentrationconcentrated
  3. customThe residue was purified by chromatography on silica gel (eluent: 10:1 DCM/MeOH)
  4. customThe product was thus obtained with the molecular weight of 434.58 (C27H34N2O3)

출처 및 근거

ORD 기록
ord-3eb1a7ed7cef47fa9c1a82b7b39355d0
출처 데이터셋
uspto-grants-2013_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08609731B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트