1,2-dihydroisoquinoline → HCID 21816560, 화합물

반응식

[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]1[C:11]([NH2:13])=[O:12].C1C2C(=CC=CC=2)C=CN1>>[CH:2]1([C:11]([NH2:13])=[O:12])[C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:9]=[CH:10][NH:1]1

참가 물질

반응물 2

HCID 4225111,2-dihydroisoquinoline

HCID 53658481HCID 53658481, 화합물

생성물 1

HCID 21816560HCID 21816560, 화합물수율 50%

실험 절차

Following the procedure for preparing amide from example 48, dihydroisoquinoline acid a (1.25 g, 6.2 mmol) prepared according to the procedures described by Deady et al. (J. Heterocyclic Chem. 2001, 38, 1185) afforded 754 mg (50%) of dihydroisoquinoline amide b as a yellow gum.

후처리

customprepared

출처 및 근거

ORD 기록: ord-1fa0bdf006e84065a7601237e69b1157
출처 데이터셋: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08609845B2

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