Chloroacetyl chloride → 2-chloro-N-methyl-N-octylacetamide

HRID 1914053

반응식

HRID 1914053 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>C(OCC)C>[CH3:6][N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3](=[O:4])[CH2:2][Cl:1]

참가 물질

4

반응물 2

HCID 6577Chloroacetyl chlorideHCID 75538Octylmethylamine

생성물 1

HCID 856901342-chloro-N-methyl-N-octylacetamide수율 66.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Chloroacetyl chloride in diethylether was added dropwise to N-methyloctylamine in diethylether at −2° C. The organic solution was returned to room temperature, followed by stirring for 3 hours. The resulting solution was successively washed with an aqueous 1 mol/L hydrochloric acid solution and water, and then dried over anhydrous sodium sulfate. After removal the solvent under vacuum, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=23:2) to give N-methyl-N-octyl-chloroacetamide (yield: 66.4%).

후처리

  1. customwas returned to room temperature
  2. washThe resulting solution was successively washed with an aqueous 1 mol/L hydrochloric acid solution and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customAfter removal the solvent under vacuum
  5. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=23:2)

출처 및 근거

ORD 기록
ord-7fa9884aa2974055beceb669fdc98013
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609898B2

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