3-Methylbenzenesulphonyl chloride → 5-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one

HRID 1914169노트

반응식

HRID 1914169 반응식
Cl.[CH:2]1([CH2:5][O:6][C:7]2[CH:8]=[C:9]([C:17]3[C:18]([CH3:30])([CH3:29])[C:19](=[O:28])[N:20]([CH:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)[N:21]=3)[CH:10]=[CH:11][C:12]=2[O:13][CH:14]([F:16])[F:15])[CH2:4][CH2:3]1.[CH3:31][C:32]1[CH:33]=[C:34]([S:38](Cl)(=[O:40])=[O:39])[CH:35]=[CH:36][CH:37]=1>>[CH:2]1([CH2:5][O:6][C:7]2[CH:8]=[C:9]([C:17]3[C:18]([CH3:30])([CH3:29])[C:19](=[O:28])[N:20]([CH:22]4[CH2:27][CH2:26][N:25]([S:38]([C:34]5[CH:35]=[CH:36][CH:37]=[C:32]([CH3:31])[CH:33]=5)(=[O:40])=[O:39])[CH2:24][CH2:23]4)[N:21]=3)[CH:10]=[CH:11][C:12]=2[O:13][CH:14]([F:15])[F:16])[CH2:3][CH2:4]1

참가 물질

3

반응물 2

HCID 27345953-Methylbenzenesulphonyl chlorideHCID 666165795-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2회

생성물 1

HCID 673851985-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one

실험 절차

The title compound is prepared analogously as described for GP1 using 5-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B3*HCl) and 3-methylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.

후처리

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by crystallization from methanol

출처 및 근거

ORD 기록
ord-7e3b76b7800142b88ff39a8e36ca9728
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609848B2

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