Potassium Hydroxide → 2-Bromo-5-phenylthiophene-3-carboxylic acid

HRID 1914541노트

반응식

HRID 1914541 반응식
[OH-].[K+].C([O:5][C:6]([C:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[S:10][C:9]=1[Br:19])=[O:7])C>O>[Br:19][C:9]1[S:10][C:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:12][C:8]=1[C:6]([OH:7])=[O:5]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 581102722-Bromo-5-phenyl-thiophene-3-carboxylic acid ethyl ester

생성물 1

HCID 581103102-Bromo-5-phenylthiophene-3-carboxylic acid수율 87%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Potassium hydroxide (0.65 g, 11.6 mmol) in water (2 mL) was added to a solution of 2-bromo-5-phenyl-thiophene-3-carboxylic acid ethyl ester (3.9 mmol) in IMS (6 mL). The reaction was stirred for 1 hour and then partitioned between diethyl ether and water. The aqueous layer was acidified to pH 7 with 1 N hydrochloric acid and further extracted with diethyl ether. The organic solution was dried over magnesium sulfate, filtered and the solvent evaporated to give the title compound (0.96 g, 87%). LCMS m/z 281.97 [M−H]− R.T.=3.64 min. (Analytical Method 5).

후처리

  1. custompartitioned between diethyl ether and water
  2. extractionfurther extracted with diethyl ether
  3. dry with materialThe organic solution was dried over magnesium sulfate
  4. filtrationfiltered
  5. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-c662300dae1e4066917c421fb4d88319
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08614209B2

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