Phosphorus pentachloride → (1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride

HRID 1914994노트

반응식

HRID 1914994 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH2:13][S:14]([Cl:17])(=[O:16])=[O:15])=[CH:5][C:4]1([CH3:19])[CH3:18])[CH3:2].C(N1C2C(=CC=[C:29]([O:32]C)C=2)C(CS(O)(=O)=O)=CC1(C)C)C.P(Cl)(Cl)(Cl)(Cl)Cl>C1C=CC=CC=1>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:32][CH3:29])[CH:11]=2)[C:6]([CH2:13][S:14]([Cl:17])(=[O:16])=[O:15])=[CH:5][C:4]1([CH3:18])[CH3:19])[CH3:2]

참가 물질

5

반응물 3

HCID 24819Phosphorus pentachlorideHCID 12138182(1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chlorideHCID 12138189(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid

생성물 1

HCID 12138190(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride수율 73%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid chloride (16) is prepared similarly to compound (9) from compound (15) and phosphorus pentachloride in dry benzene. The acid chloride that is obtained is immediately used for further reaction.

출처 및 근거

ORD 기록
ord-37bd0ec4612246d6abbed01f9b4f61f0
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08614317B2

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