Sodium Methoxide → 5-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

HRID 1915561노트

반응식

HRID 1915561 반응식
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6](Cl)[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1.[CH3:18][O-:19].[Na+]>CO.ClCCl.O>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([O:19][CH3:18])[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1

참가 물질

6

반응물 2

HCID 10942334Sodium MethoxideHCID 594278075,7-Dichloro-6-phenylpyrazolo[1,5-a]pyrimidine

생성물 1

HCID 866306725-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 6344Dichloromethane용매2회

실험 절차

1.00 g 5,7-dichloro-6-phenylpyrazolo[1,5-a]pyrimidine (prepared as described under example 19) are dissolved in 20 ml methanol and 20 ml dichlormethane. 1.2 g sodium methylate is added at 0° C. and stirred at room temperature for 2 h. The solution is diluted with water and dichloromethane. The organic phase separated and the water phase is extracted with dichloromethane. The combined organic layers are dried over Na2SO4 and the solvent is evaporated. The crude product is used without further purification.

후처리

  1. customThe organic phase separated
  2. extractionthe water phase is extracted with dichloromethane
  3. dry with materialThe combined organic layers are dried over Na2SO4
  4. customthe solvent is evaporated
  5. customThe crude product is used without further purification

출처 및 근거

ORD 기록
ord-168c418ed45f4dfebef77fe8961274c6
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08614218B2

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