Ethanolamine → N-(2-Hydroxyethyl)-2,2-dimethylpropanamide

HRID 1916342노트

반응식

HRID 1916342 반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].[OH-].[K+].[C:7](Cl)(=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9]>O>[OH:2][CH2:1][CH2:3][NH:4][C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9]

참가 물질

5

반응물 3

HCID 700EthanolamineHCID 14797Potassium HydroxideHCID 62493Pivaloyl chloride

생성물 1

HCID 15074197N-(2-Hydroxyethyl)-2,2-dimethylpropanamide수율 50.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred 4° aqueous solution containing ethanolamine (610 mg, 10 mmol), KOH (840 mg, 15 mmol) and H2O (15 mL) was added pivaloyl chloride (1.44 g, 12 mmol) whereupon the reaction was allowed to slowly warm to 20°. After stirring for 18 hr, the solution was extracted 4× with EtOAc,. The combined organic layers were washed with brine, dried over Na2SO4 prior to concentration using a rotary evaporator to yield 737 mg of a clear oil.

후처리

  1. temperatureto slowly warm to 20°
  2. extractionthe solution was extracted 4× with EtOAc
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationto concentration
  6. customa rotary evaporator

출처 및 근거

ORD 기록
ord-eb83732cd0b04f12ab314b4768a224b3
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618115B2

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