Dichloromethane → 4-{[2-(3,5-Difluoro-phenyl)-acetylamino]-methyl}-4-(4-iodo-phenyl)-piperidine

HRID 191640

반응식

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]2)([CH2:21][NH:22][C:23]([CH2:24][c:25]2[cH:26][c:27]([F:32])[cH:28][c:29]([F:31])[cH:30]2)=[O:33])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:41][CH2:42][Cl:43].[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[NH:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]2)([CH2:21][NH:22][C:23]([CH2:24][c:25]2[cH:26][c:27]([F:32])[cH:28][c:29]([F:31])[cH:30]2)=[O:33])[CH2:12][CH2:13]1

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 685306044-{[2-(3,5-Difluoro-phenyl)-acetylamino]-methyl}-4-(4-iodo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 224903764-{[2-(3,5-Difluoro-phenyl)-acetylamino]-methyl}-4-(4-iodo-phenyl)-piperidine

출처 및 근거

ORD 기록: ord-aa6d0048c73f4443ba2bd3d1b9ee566d
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

연결된 노트

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