Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pentenone → ethyl 4,5-dihydro-3,5-dimethyl-1H-pyrazole-1-acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pentenone | HCID 12248 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) | HCID 11593468 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | ethyl 4,5-dihydro-3,5-dimethyl-1H-pyrazole-1-acetate | HCID 67378927 | 14.1% |
반응 단계
A mixture of ethyl hydrazinoacetate hydrochloride (1.55 g, 10 mmol), 3-pentene-2-one (0.95 mL, 10 mmol) and sodium bicarbonate (1.00 g, 11.9 mmol) in ethanol (10 mL) was stirred at room temperature overnight. The reaction mixture was then filtered and concentrated under reduced pressure. The resulting oil was purified by medium pressure liquid chromatography on silica gel (0 to 100% gradient of ethyl acetate in hexanes as eluant) to provide the title compound as a yellow oil (0.26 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618137B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-cef1dd2f91c74bdc98647778372a4bf9 |
| 출처 메모 | uspto-grants-2013_12 |