참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,5-Dibromopyridine | HCID 69353 | — |
| 반응물 | 4-(3-Butyn-1-yl)benzenemethanol | HCID 23596609 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | {4-[4-(5-Bromo-pyridin-2-yl)-but-3-ynyl]-phenyl}-methanol | HCID 69070552 | — |
반응 단계
Under an N2 atmosphere 130 mg (0.67 mmol) CuI and 300 mg (0.42 mmol) Pd(PPh3)2Cl2 are added to a solution of 2.0 g (12.48 mmol) (4-but-3-ynyl-phenyl)-methanol and 3.2 g (13.1 mmol) 2,5-dibromopyridine in 80 mL triethylamine and the reaction mixture is stirred for 1.5 h at 50° C. The solvent is eliminated in vacuo, the residue dissolved in a little DCM and purified by chromatography on silica gel (gradient: cyc/EtOAc 4:1 to cyc/EtOAc 3:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08618132B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_12 |
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| ORD ID | ord-6b15665bd4dd4132a87207ea712638f1 |
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| 출처 메모 | uspto-grants-2013_12 |
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