Methanol → Benzoic acid, 2-hydroxy-5-iodo-3-methyl-, methyl ester

HRID 1916565

반응식

HRID 1916565 반응식
[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([I:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(Cl)(Cl)=O.[CH3:17]O>>[OH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([I:12])=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl Chloride2회HCID 159086852-Hydroxy-5-iodo-3-methylbenzoic acid

생성물 1

HCID 14172484Benzoic acid, 2-hydroxy-5-iodo-3-methyl-, methyl ester

실험 절차

A solution of 2.0 g (7.19 mmol) 2-hydroxy-5-iodo-3-methyl-benzoic acid in 5.0 mL thionyl chloride (69.0 mmol) is stirred for 20 min at 80° C. Thionyl chloride is eliminated i.vac. and the residue is combined with 20 mL MeOH and stirred for 20 min at RT. The product is precipitated out of the reaction. MeOH is eliminated i.vac. down to 5 mL and the residue is suction filtered. The product is further reacted without any more purification.

후처리

  1. customThe product is precipitated out of the reaction
  2. filtrationfiltered
  3. customThe product is further reacted without any more purification

출처 및 근거

ORD 기록
ord-14bc186e27e24c299a0c3914c5a30543
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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