Sodium Bicarbonate → HCID 67362954, 화합물

HRID 1916622노트

반응식

HRID 1916622 반응식
[CH3:1][NH:2][C:3]1[C:4]([NH2:15])=[CH:5][C:6]([CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:7][CH:8]=1.[C:16]([O-])(O)=O.[Na+]>C(O)=O>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([CH2:9][N:10]3[CH2:11][CH2:12][CH2:13][CH2:14]3)=[CH:5][C:4]=2[N:15]=[CH:16]1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 85969746HCID 85969746, 화합물

생성물 1

HCID 67362954HCID 67362954, 화합물

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A solution of 850 mg (4.14 mmol) N1-methyl-4-pyrrolidin-1-ylmethyl-benzene-1,2-diamine in 4 mL formic acid is refluxed for 1.5 h. It is made alkaline with 250 mL semisaturated NaHCO3 solution and extracted twice with 70 mL EtOAc. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac.

후처리

  1. extractionextracted twice with 70 mL EtOAc
  2. dry with materialThe organic phase is dried over MgSO4

출처 및 근거

ORD 기록
ord-1de7f51983ae4f0498f28d2e5bcd3894
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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