Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Azobisisobutyronitrile → 6-Bromo-2-(bromomethyl)quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 6-Bromo-2-methylquinoline | HCID 522885 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 6-Bromo-2-(bromomethyl)quinoline | HCID 58970532 | — |
반응 단계
148 mg (1.00 mmol) α,α-azoisobutyronitrile and 8.01 g (45.0 mmol) N-bromosuccinimide are added successively to a solution of 10.0 g (45.0 mmol) 6-bromo-2-methyl-quinoline in 60 mL carbon tetrachloride. The reaction mixture is refluxed for 8 h. It is filtered and the filtrate is washed twice with water. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac. The purification is carried out by column chromatography on silica gel (PE/EtOAc 4:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618132B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-eeef34e06cb945688a8dc1fc86e388de |
| 출처 메모 | uspto-grants-2013_12 |