Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 6-Bromo-2-pyrrolidin-1-ylmethyl-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 6-Bromo-2-(bromomethyl)quinoline | HCID 58970532 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-Bromo-2-pyrrolidin-1-ylmethyl-quinoline | HCID 67364796 | — |
반응 단계
4.60 g (15.28 mmol) 6-bromo-2-bromomethyl-quinoline are added to a solution of 1.40 mL (16.8 mmol) pyrrolidine and 6.34 g (45.9 mmol) K2CO3 in 50 mL acetonitrile. The reaction is stirred overnight at RT and then the inorganic salts are filtered off. The organic phase is washed with water and the aqueous phase is extracted with EtOAc. The combined organic extracts are dried over MgSO4 and the solvent is eliminated i.vac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618132B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-e81953fcf971414f8406f0421b472477 |
| 출처 메모 | uspto-grants-2013_12 |