5-Bromo-2-ethynylpyridine → 5-Bromo-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine

HRID 1916680노트

반응식

HRID 1916680 반응식
I[C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([CH3:15])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[Br:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]#[CH:26])=[N:23][CH:24]=1>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]#[C:26][C:2]2[CH:17]=[CH:16][C:5]([O:6][CH2:7][CH2:8][N:9]3[CH2:14][CH2:13][CH:12]([CH3:15])[CH2:11][CH2:10]3)=[CH:4][CH:3]=2)=[N:23][CH:24]=1

참가 물질

3

반응물 2

HCID 139797345-Bromo-2-ethynylpyridineHCID 690610171-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine

생성물 1

HCID 690601725-Bromo-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine

실험 절차

Prepared according to general working method I from 1-[2-(4-iodo-phenoxy)-ethyl]-4-methyl-piperidine (345 mg, 1.00 mmol) and 5-bromo-2-ethynyl-pyridine (83 mg, 0.39 mmol).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-069bb95d5ce44f66b402b5a52ed9a281
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

반응 노트

불러오는 중…