Water → HCID 67363953, 화합물

HRID 1916692노트

반응식

HRID 1916692 반응식
I[C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[CH:26])=[N:23][CH:24]=2)=[CH:15][CH:14]=1.O.CCOC(C)=O>N1CCCCC1.[Cu]I>[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]#[C:26][C:2]3[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[CH:4][CH:3]=3)=[N:23][CH:24]=2)=[CH:17][CH:18]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 35132082-(4-Iodophenoxy)ethanolHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

생성물 1

HCID 67363953HCID 67363953, 화합물

시약·촉매·용매 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 8082Piperidine용매

실험 절차

Under an argon atmosphere 253 mg (0.22 mmol) tetrakis-triphenylphosphane-palladium and 42 mg (0.22 mmol) CuI are added to a solution of 2.9 g (11 mmol) 2-(4-iodo-phenoxy)-ethanol and 2.35 g (11 mmol) 5-(4-chloro-phenyl)-2-ethynyl-pyridine in 50 mL piperidine and the reaction mixture is stirred for 30 min at RT. The solvent is eliminated i.vac., the residue is combined with water and stirred with EtOAc. The product precipitated is suction filtered and dried.

후처리

  1. customThe product precipitated
  2. filtrationfiltered
  3. customdried

출처 및 근거

ORD 기록
ord-45fe597784e64715ae44abf0a7de67b6
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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