Piperidine → HCID 59835795, 화합물

HRID 1916695노트

반응식

HRID 1916695 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CS(O[CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]#[C:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)=[CH:25][N:24]=2)=[CH:17][CH:16]=1)(=O)=O>CN(C=O)C>[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([C:26]2[CH:27]=[CH:28][C:23]([C:22]#[C:21][C:18]3[CH:19]=[CH:20][C:15]([O:14][CH2:13][CH2:12][N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:16][CH:17]=3)=[N:24][CH:25]=2)=[CH:30][CH:31]=1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 86601132HCID 86601132, 화합물

생성물 1

HCID 59835795HCID 59835795, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

99 μL (1.0 mmol) piperidine are added to a solution of 85.6 mg (0.2 mmol) of 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethyl methanesulphonate in 2 mL DMF and the reaction mixture is stirred for 18 h at RT. The solvent is distilled off i.vac., the residue is stirred with 5 mL water and 40 mL DCM, the organic phase is separated off and dried with Na2SO4. After the desiccant and solvent have been eliminated the residue is triturated with 20 mL diethyl ether and suction filtered.

후처리

  1. distillationThe solvent is distilled off i.vac
  2. stirring, the residue is stirred with 5 mL water and 40 mL DCM
  3. customthe organic phase is separated off
  4. dry with materialdried with Na2SO4
  5. customis triturated with 20 mL diethyl ether and suction
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-a16706884bd94511a5aff1ec8201bdbd
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618132B2

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