Formaldehyde → Methyl hydroxymethyl(2-(4-methoxyphenylthio)ethyl)carbamate

HRID 1917064노트

반응식

HRID 1917064 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH2:10][CH2:11][NH:12][C:13](=[O:16])[O:14][CH3:15])=[CH:5][CH:4]=1.C=O.[C:19]([O-])([O-])=[O:20].[Cs+].[Cs+]>C1COCC1>[OH:20][CH2:19][N:12]([CH2:11][CH2:10][S:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[C:13](=[O:16])[O:14][CH3:15]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 10796Cesium carbonateHCID 57864658Methyl 2-(4-methoxyphenylthio)ethylcarbamate

생성물 1

HCID 57864666Methyl hydroxymethyl(2-(4-methoxyphenylthio)ethyl)carbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

A mixture of compound 7 (2.0 g), paraformaldehyde (1.5 g), Cs2CO3 (1.2 eq.) in THF (50 mL) was stirred at 70° C. for 3 hours. Filtration and concentration of the solvent gave the title product 9 as pure white solid. Yield: 2.2 g, 98%.

후처리

  1. filtrationFiltration and concentration of the solvent

출처 및 근거

ORD 기록
ord-4d9b234d2847477695bb763e7c762975
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618282B2

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