Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Benzyl 4-(2-(4-methoxyphenylthio)ethylcarbamoyl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Triphosgene | HCID 94429 | — |
| 반응물 | Benzyl piperidine-1-carboxylate | HCID 228749 | — |
| 반응물 | Ethanamine, 2-[(4-methoxyphenyl)thio]- | HCID 12261932 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl 4-(2-(4-methoxyphenylthio)ethylcarbamoyl)piperazine-1-carboxylate | HCID 68626717 | — |
반응 단계
To a solution of compound 1 (183 mg) in CH2Cl2 (10 mL) was added triphosgene (0.7 eq.) and triethylamine (1.0 eq.) at 0° C. The reaction mixture was stirred for 1 h. at r.t., and N-Cbz-piperidine (1.5 eq.) and Et3N (0.5 mL) were added. The reaction mixture was stirred overnight and washed with 1N HCl and sat NaHCO3 (3×5 mL). The solvents were removed by evaporation under reduced pressure to give the title product 18, which was purified by chromatography (SiO2, CH2Cl2/EtOAc 10:1). Yield: 360 mg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618282B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-44b55b8362cc4f0b951d1671d0c489a8 |
| 출처 메모 | uspto-grants-2013_12 |