Formaldehyde → 1-(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)prop-2-en-1-one
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH2:10][CH2:11][NH:12][C:13](=[O:16])[CH:14]=[CH2:15])=[CH:5][CH:4]=1.C=O.[C:19]1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[S:9][CH2:10][CH2:11][N:12]([C:13](=[O:16])[CH:14]=[CH2:15])[CH2:19][C:5]=2[CH:4]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of compound 32 (280 mg), paraformaldehyde (600 mg), p-toluenesulfonic acid (140 mg) in benzene (7.0 mL) was stirred at 80° C. for 16 h. The reaction mixture was filtered and washed with sat. NaHCO3 solution (2×3 mL). The solvents were removed by evaporation under reduced pressure to give product 33 as an oil. Yield: 253 mg, 86%.
후처리
- filtrationThe reaction mixture was filtered
- washwashed with sat. NaHCO3 solution (2×3 mL)
- customThe solvents were removed by evaporation under reduced pressure
출처 및 근거
- ORD 기록
- ord-68d546a2063d4c7aac7ce93ac4a565f2
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08618282B2
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