5-Tert-butyl-3-isocyanato-1,2-oxazole → 1-(5-Tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea

HRID 1917646노트

반응식

HRID 1917646 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:9])=[C:6]([OH:8])[CH:7]=1.[C:10]([C:14]1[O:18][N:17]=[C:16]([N:19]=[C:20]=[O:21])[CH:15]=1)([CH3:13])([CH3:12])[CH3:11]>C1(C)C=CC=CC=1>[C:10]([C:14]1[O:18][N:17]=[C:16]([NH:19][C:20]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([F:9])=[C:6]([OH:8])[CH:7]=2)=[O:21])[CH:15]=1)([CH3:13])([CH3:11])[CH3:12]

참가 물질

4

반응물 2

HCID 129188385-Tert-butyl-3-isocyanato-1,2-oxazoleHCID 226414135-Amino-2-fluorophenol

생성물 1

HCID 668767761-(5-Tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
70 °C

실험 절차

A mixture of 5-amino-2-fluorophenol (1.3 g, 10.2 mmol) and 5-tert-butyl-3-isocyanatoisoxazole (1.7 g, 10.2 mmol) in toluene (60 mL) was heated at 70° C. overnight. The solid was filtered and dried under vacuum to afford 1-(5-tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea as solid.

후처리

  1. filtrationThe solid was filtered
  2. customdried under vacuum

출처 및 근거

ORD 기록
ord-68a309d3b3634d0194fac8fb0954a47f
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618289B2

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