Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Malic Acid → Sunitinib Malate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Malic Acid | HCID 525 | — |
| 반응물 | 1-Propanol | HCID 1031 | — |
| 반응물 | Sunitinib | HCID 5329102 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | Sunitinib Malate | HCID 6456015 | — |
반응 단계
2 g of sunitinib base were suspended in 6 ml of NMP under stirring at RT. 0.673 g of Malic acid were added to the mixture and the temperature was set at 40° C. 40 ml n-propanol were dropped in 30 minutes, the suspension was cooled to 0° C., filtered and washed with 10 ml n-propanol. Dried at 70° C. under vacuum for 16 h.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618309B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-3999f844e5a14739bf783d924cfdb0e2 |
| 출처 메모 | uspto-grants-2013_12 |