Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-Cyclopropyl-1,2-oxazole-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ethyl 5-cyclopropylisoxazole-3-carboxylate | HCID 55251041 | — |
| 생성물 | 5-Cyclopropyl-1,2-oxazole-3-carboxylic acid | HCID 1092113 | 96% |
반응 단계
The mixture of ethyl 5-cyclopropylisoxazole-3-carboxylate (0.550 g; 3.04 mmol) and 1M aqueous sodium hydroxide (9.11 mL; 9.11 mmol) was stirred at room temperature during the weekend (72 h). The pH of the solution was adjusted to 1 by addition of 6N hydrochloric acid and extracted with ethyl acetate. The ethyl acetate layer was dried over magnesium sulfate and was evaporated to furnish 0.446 g (96%) of 5-cyclopropylisoxazole-3-carboxylic acid as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618138B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-3bed70955ccc44f5a136ad0901dc38cc |
| 출처 메모 | uspto-grants-2013_12 |