Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
PyBOP → N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(4-methoxyphenyl)-2-oxopyrrolidine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | PyBOP | HCID 2724699 | — |
| 반응물 | 5-Chloro-1H-indole-3-ethylamine monohydrochloride | HCID 2827494 | — |
| 반응물 | 1-(4-Methoxyphenyl)-2-oxo-3-pyrrolidinecarboxylic acid | HCID 3373117 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(4-methoxyphenyl)-2-oxopyrrolidine-3-carboxamide | HCID 66832008 | 42.3% |
반응 단계
A mixture of 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.098 g; 0.425 mmol), PyBOP (0.332 g; 0.638 mmol), N,N-diisoprpylethylamine (0.220 mL; 1.28 mmol) and 1-(4-methoxyphenyl)-2-oxopyrrolidine-3-carboxylic acid (0.100 g; 0.425 mmol) was stirred in DMF (3 mL) overnight. The reaction mixture was partitioned between ethyl acetate and sodium hydrogen sulfate, the organic layer was washed with sodium carbonate, brine, dried and concentrated under reduced pressure. The crude mixture was purified flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane) to yield 0.074 g (42%) of the title compound as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08618138B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-b8c48cae8101455e97de7d878ab507a2 |
| 출처 메모 | uspto-grants-2013_12 |