Triethylamine → N-(2-(5-chloro-1H-indol-3-yl)ethyl)-5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carboxamide

HRID 1918776

반응식

HRID 1918776 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH2:14].[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20]1[N:24]([CH3:25])[N:23]=[C:22]([C:26](Cl)=[O:27])[CH:21]=1.C(N(CC)CC)C.C(OCC)(=O)C>ClCCl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:26]([C:22]1[CH:21]=[C:20]([C:16]2[O:15][CH:19]=[CH:18][CH:17]=2)[N:24]([CH3:25])[N:23]=1)=[O:27]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 28274945-Chloro-1H-indole-3-ethylamine monohydrochlorideHCID 185258005-(2-Furyl)-1-methyl-1H-pyrazole-3-carbonyl chloride

생성물 1

HCID 66831973N-(2-(5-chloro-1H-indol-3-yl)ethyl)-5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carboxamide수율 98%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

This compound was obtained following Method B starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g, 0.432 mmol), 5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carbonyl chloride (0.096 g; 0.454 mmol), and triethylamine (0.156 mL; 1.08 mmol) in dichloromethane (2.87 mL). Flash chromatography on silica gel eluting with 5% of ethyl acetate in dichloromethane gave 0.121 g (98%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carboxamide as a solid.

후처리

  1. customThis compound was obtained

출처 및 근거

ORD 기록
ord-097e0861d9d34516a38570a2297fdaeb
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08618138B2

연결된 노트

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