Morpholine → 5-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidine

HRID 1919359노트

반응식

HRID 1919359 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][C:9]([CH3:11])=[N:8][C:6]=2[N:7]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>CO.CCOC(C)=O.O>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH3:11])=[N:8][C:6]=2[N:7]=1

참가 물질

6

반응물 2

HCID 8083MorpholineHCID 582349525,7-Dichloro-2-methylthiazolo[4,5-d]pyrimidine

생성물 1

HCID 582349545-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidine수율 90%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 5,7-dichloro-2-methyl-thiazolo[4,5-d]pyrimidine (92 mg, 0.42 mmol) in MeOH (3 mL) was added morpholine (81 μL, 0.93 mmol) and the mixture stirred at RT for 1 h. The reaction mixture was diluted with EtOAc and H2O. The organic layer was isolated, washed with brine, then dried (MgSO4) and concentrated in vacuo. The resultant residue was purified by column chromatography to give the title compound as a cream solid (102 mg, 90%).

후처리

  1. customThe organic layer was isolated
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe resultant residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-eaea9edf5a8c483c9cb144b3e1addc39
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08168633B2

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