Azane;hydrate → 2-Methylthiazole-5-carboxamide

반응식

[CH3:1][C:2]1[S:3][C:4]([C:7]([O:9]C)=O)=[CH:5][N:6]=1.O.[NH3:12]>>[CH3:1][C:2]1[S:3][C:4]([C:7]([NH2:12])=[O:9])=[CH:5][N:6]=1

참가 물질

반응물 2

HCID 12896473Azane;hydrate

HCID 21427465Methyl 2-methyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 233223662-Methylthiazole-5-carboxamide수율 73%

실험 절차

1.4 g Methyl 2-methylthiazol-5-carboxylate was added to 25 ml ammonia water, to carry out reaction at room temperature for 3 hr. The reaction product was cooled down, filtered, and washed with water to obtain 0.95 g a white powdery solid (73%) with mp 202-205 (C.

후처리

customreaction at room temperature for 3 hr
temperatureThe reaction product was cooled down
filtrationfiltered
washwashed with water

출처 및 근거

ORD 기록: ord-c38b706d80a24896bfb56f94447db64e
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08168642B2

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