4-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl benzyl ether → 4-(1,1,1,3,3,3-Hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenol

HRID 1919753노트

반응식

HRID 1919753 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([O:24][CH2:25][O:26][CH3:27])([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])=[CH:11][C:10]=1[CH2:28][CH2:29][CH3:30])C1C=CC=CC=1>[C].[Pd].CO>[F:17][C:16]([F:18])([F:19])[C:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([CH2:28][CH2:29][CH3:30])[CH:11]=1)([O:24][CH2:25][O:26][CH3:27])[C:20]([F:21])([F:23])[F:22]

참가 물질

4

반응물 1

HCID 592011484-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl benzyl ether

생성물 1

HCID 592010374-(1,1,1,3,3,3-Hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenol수율 104.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A 10% palladium carbon catalyst (30 mg) was added to a mixed solution of 4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl benzyl ether (264.9 mg, 0.61 mmol) in methanol (10 mL), followed by hydrogenation overnight. The catalyst was separated from the reaction solution by filtration, followed by concentration under reduced pressure to obtain 221.1 mg of the title compound (yield: 100%) as a pale yellow oil.

후처리

  1. customThe catalyst was separated from the reaction solution by filtration
  2. concentrationfollowed by concentration under reduced pressure

출처 및 근거

ORD 기록
ord-fa4bdb4d15b34aa0813217f1dea8373d
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08168666B2

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