Ethanol hydrochloride → 3-[4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione

HRID 1919765노트

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HRID 1919765 반응식
Cl.C(O)C.[F:5][C:6]([F:41])([F:40])[C:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]([CH3:34])([CH3:33])[N:29]([CH3:35])[C:28]2=[O:36])=[C:18]([CH2:37][CH2:38][CH3:39])[CH:17]=1)([O:12]COC)[C:8]([F:11])([F:10])[F:9]>>[F:41][C:6]([F:5])([F:40])[C:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH2:25][CH2:26][N:27]2[C:31](=[O:32])[C:30]([CH3:33])([CH3:34])[N:29]([CH3:35])[C:28]2=[O:36])=[C:18]([CH2:37][CH2:38][CH3:39])[CH:17]=1)([OH:12])[C:8]([F:11])([F:10])[F:9]

참가 물질

3

반응물 2

HCID 21887872Ethanol hydrochlorideHCID 249910743-[4-[4-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione

생성물 1

HCID 249910753-[4-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione수율 82%

실험 절차

Hydrochloric acid-ethanol (2 mol/L, 2 mL) was added to 3-[4-[4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]butyl]-1,5,5-trimethylimidazolidine-2,4-dione (55.7 mg, 0.11 mmol), followed by stirring at room temperature for one hour. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=2:1) to obtain 41.8 mg of the title compound (yield: 82%) as a colorless crystalline powder.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=2:1)

출처 및 근거

ORD 기록
ord-a48bdc306b234139afa9579015d3ee0b
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08168666B2

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