Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1919893생성일: 2026년 10월 26일
Benzoic Acid → Methyl 4-{2-[benzoyl(2,4-dimethoxybenzyl)amino]-3-[(4-chlorophenyl)amino]-3-oxopropyl}benzoate
https://huagongshe.com/reaction/1919893
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| 반응물 | 4-Chlorophenyl isocyanide | HCID 74670 | — |
| 반응물 | 2,4-Dimethoxybenzylamine | HCID 597250 | — |
| 반응물 | Methyl 4-(2-oxoethyl)benzoate | HCID 13844675 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 4-{2-[benzoyl(2,4-dimethoxybenzyl)amino]-3-[(4-chlorophenyl)amino]-3-oxopropyl}benzoate | HCID 57611867 | — |
반응 단계
Methyl 4-formylmethylbenzoate (56.3 mg, 0.316 mmol, 4-chlorophenyl isocyanide (43.5 mg, 0.316 mmol), 1-(2,4-dimethoxyphenyl)methanamine (56.9 μL, 0.379 mmol) and benzoic acid (38.6 mg, 0.316 mmol) were dissolved in 100 μL of trifluoroethanol and heated at 50° C. for 2 hours. The reaction mixture was diluted with 2 mL of methanol and purified by reversed phase HPLC to afford the desired product. MS cal'd 587.2 (MH+), exp 587.2 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08168658B2 |
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| 출처 데이터셋 | uspto-grants-2012_05 |
|---|
| ORD ID | ord-ac5957fb35274ce48a08668e57be7c1a |
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| 출처 메모 | uspto-grants-2012_05 |
|---|
