1,1'-sulphonylbis-1H-imidazole → 4-Amino-5-ethoxy-1,2,3-benzoxathiazine 2,2-dioxide

HRID 1920713노트

반응식

HRID 1920713 반응식
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[C:11](=[NH:13])[NH2:12])[CH3:2].[S:14](N1C=CN=C1)(N1C=CN=C1)(=[O:16])=[O:15]>O>[NH2:13][C:11]1[C:5]2[C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH:8]=[CH:7][C:6]=2[O:10][S:14](=[O:16])(=[O:15])[N:12]=1

참가 물질

4

반응물 2

HCID 816091,1'-sulphonylbis-1H-imidazoleHCID 1360739132-Ethoxy-6-hydroxybenzenecarboximidamide

생성물 1

HCID 462386994-Amino-5-ethoxy-1,2,3-benzoxathiazine 2,2-dioxide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.25 g (1.39 mmol) of 2-ethoxy-6-hydroxybenzenecarboximidamide is stirred without solvent with 0.65 g (3.28 mmol) of 1,1′-sulphonyldiimidazole at 130° C. for 18 hours. Cooling is followed by stirring the mixture with water and removing with dichloromethane. The organic phase is dried over magnesium sulphate and concentrated under reduced pressure. This gives 0.2 g of a pale yellow, crystalline material.

후처리

  1. temperatureCooling
  2. customremoving with dichloromethane
  3. dry with materialThe organic phase is dried over magnesium sulphate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-db444358b5064ccea948f1c2d8203590
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173641B2

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