Bis(2-chloroethyl)amine → N-[2-Oxo-8-(piperazin-1-yl)-2H-1-benzopyran-3-yl]acetamide

반응식

[NH2:1][C:2]1[C:11]2[O:10][C:9](=[O:12])[C:8]([NH:13][C:14](=[O:16])[CH3:15])=[CH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]Cl>>[N:1]1([C:2]2[C:11]3[O:10][C:9](=[O:12])[C:8]([NH:13][C:14](=[O:16])[CH3:15])=[CH:7][C:6]=3[CH:5]=[CH:4][CH:3]=2)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1

참가 물질

반응물 2

HCID 9533Bis(2-chloroethyl)amine

HCID 21792250N-(8-Amino-2-oxo-2H-1-benzopyran-3-yl)acetamide

생성물 1

HCID 59427368N-[2-Oxo-8-(piperazin-1-yl)-2H-1-benzopyran-3-yl]acetamide

실험 절차

Step 4 was the alkylation of N-(8-amino-2-oxo-2H-1-benzopyran-3-yl)-acetamide (4*) with bis-chloroethylamine yielding N-(8-(1-piperazinyl)-2-oxo-2H-1-benzopyran-3-yl-)acetamide (5*).

출처 및 근거

ORD 기록: ord-df630dbea199459585673af5ab3e9486
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08173660B2

반응 노트

불러오는 중…