Potassium Cyanide → (1-[(tert-butoxycarbonyl)oxy]-6-methoxy-1H-indazol-3-yl)acetonitrile

HRID 1921262노트

반응식

HRID 1921262 반응식
[C-:1]#[N:2].[K+].[C:4]([O:8][C:9]([O:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([O:21][CH3:22])[CH:19]=2)[C:14]([CH2:23]Br)=[N:13]1)=[O:10])([CH3:7])([CH3:6])[CH3:5]>O.C(O)C>[C:4]([O:8][C:9]([O:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([O:21][CH3:22])[CH:19]=2)[C:14]([CH2:23][C:1]#[N:2])=[N:13]1)=[O:10])([CH3:7])([CH3:6])[CH3:5]

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 231171601-[(tert-butoxycarbonyl)oxy]-6-methoxy-3-bromomethyl-1H-indazole

생성물 1

HCID 23117149(1-[(tert-butoxycarbonyl)oxy]-6-methoxy-1H-indazol-3-yl)acetonitrile수율 50%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

KCN (5.73 g, 88 mmol) in 23 ml of H2O was added dropwise at 0° C. to 1-[(tert-butoxycarbonyl)oxy]-6-methoxy-3-bromomethyl-1H-indazole (10.5 g, 30.08 mmol) in 80 ml of ethanol and stirred at room temperature for 1 h30. The mixture was poured into water, and extracted with ethyl acetate. The organic layer was dried over Na2SO4. Concentration and precipitation in diisopropyl ether gave the expected product (4.42 g, 50% as solid).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationConcentration and precipitation in diisopropyl ether

출처 및 근거

ORD 기록
ord-970586ed9c1e4deca489af392aab1d60
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173679B2

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