Morpholine → HCID 59558570, 화합물

HRID 1921321노트

반응식

HRID 1921321 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10]Br)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C(N(CC)CC)C>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 442031405-Bromo-2-(bromomethyl)benzonitrile

생성물 1

HCID 59558570HCID 59558570, 화합물수율 74.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-Bromo-2-bromomethylbenzonitrile (2.50 g, 9.1 mmol) is added portionwise to a stirred solution of morpholine (828 μL, 9.5 mmol) and triethylamine (1.27 mL, 9.1 mmol) in methanol (2 mL). After 4 hr, the solvent is removed and the residue is suspended in water that is made basic with sodium hydroxide and then extracted with ethyl acetate. The extract is dried, filtered, and concentrated to give 5-bromo-2-(morpholin-4-yl)methylbenzonitrile (1.90 g, 74%) as a cream solid.

후처리

  1. customthe solvent is removed
  2. extractionextracted with ethyl acetate
  3. customThe extract is dried
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-97029078feef4f5a96ce09f9e59535e8
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173682B2

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