Water → HCID 67492305, 화합물

HRID 1921327노트

반응식

HRID 1921327 반응식
[Br:1]Br.[CH3:3][C:4]1[NH:5][C:6](=[O:14])[C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2.O>C(O)(=O)C>[Br:1][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:14])[NH:5][C:4]=1[CH3:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 32444773-Methyl-1,2-dihydroisoquinolin-1-one

생성물 1

HCID 67492305HCID 67492305, 화합물수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of bromine 491 mL, 9.58 mmol) in acetic acid (10 mL) is added to a stirred solution of 3-methyl-2H-isoquinolin-1-one (1.45 g, 9.12 mmol) in acetic acid (1 mL). After 3 hr, water (60 mL) is added and the resulting solids are collected by filtration to afford 4-bromo-3-methyl-2H-isoquinolin-1-one (1.90 g, 88% yield) as a white solid. LC/MS: MS m/e=238/240 (M+H); RT 2.97 min.

후처리

  1. filtrationthe resulting solids are collected by filtration

출처 및 근거

ORD 기록
ord-8baa1951e96148f0a2d3d109f7d27070
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173682B2

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