Potassium Iodide → 3-ethyl-6-methyl-5-thiophen-2-yl-1H-pyridin-2-one

HRID 1921380노트

반응식

HRID 1921380 반응식
[CH2:1]([C:3]1[C:4]([O:15]C)=[N:5][C:6]([CH3:14])=[C:7]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=1)[CH3:2].[I-].[K+].C(#N)C.Cl[Si](C)(C)C>O>[CH2:1]([C:3]1[C:4](=[O:15])[NH:5][C:6]([CH3:14])=[C:7]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=1)[CH3:2]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 6342AcetonitrileHCID 6397ChlorotrimethylsilaneHCID 11673096HCID 11673096, 화합물

생성물 1

HCID 674922683-ethyl-6-methyl-5-thiophen-2-yl-1H-pyridin-2-one수율 90%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

To a solution of 3-ethyl-2-methoxy-6-methyl-5-(thiophen-2-yl)pyridine (6.15 g, 26.36 mmol) of the above reaction, potassium iodide (8.75 g, 52.71 mmol) and acetonitrile (80 mL) is added chlorotrimethylsilane (6.69 mL, 52.71 mmol) and the resulting cloudy mixture is heated to 80° C. for 2 hr. The reaction is cooled, poured into water and the solids collected by filtration, washed with water, with ethyl acetate and dried giving 3-ethyl-6-methyl-5-(thiophen-2-yl)-1H-pyridin-2-one as a yellow solid (90% yield).

후처리

  1. temperatureThe reaction is cooled
  2. filtrationthe solids collected by filtration
  3. washwashed with water, with ethyl acetate
  4. customdried

출처 및 근거

ORD 기록
ord-42de59cfb65848209e4f91f7849f0b89
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173682B2

반응 노트

불러오는 중…