Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[3-chloro-4-(4-methyl-piperazin-1-yl)-phenyl]-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Chloro-4-(4-methylpiperazin-1-yl)aniline | HCID 820343 | — |
| 반응물 | 5,8-Dibromoimidazo[1,2-a]pyrazine | HCID 53485949 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Ammonia | HCID 222 | — |
| 생성물 | (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[3-chloro-4-(4-methyl-piperazin-1-yl)-phenyl]-amine | HCID 59023078 | 39.5% |
반응 단계
Following the general procedure for amine displacement using 5,8-dibromoimidazo[1,2-a]pyrazine (0.20 g, 0.72 mmol), 3-chloro-4-(4-methyl-piperazin-1-yl)-phenylamine (0.263 g, 1.08 mmol) and DIPEA (0.19 mL, 1.08 mmol) in iPrOH (5 mL). Purification of the crude compound by silica gel column chromatography, eluting with 95:5 DCM:NH3 (7M in MeOH), affords the title compound (60 mg, 20%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08173656B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-215de1a3f8f5476fbfe45a06ee196bd7 |
| 출처 메모 | uspto-grants-2012_05 |