Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1921781생성일: 2026년 10월 26일
Dabco → (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-amine
https://huagongshe.com/reaction/1921781
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dabco | HCID 9237 | — |
| 반응물 | 4-((1-Methyl-4-piperidinyl)methoxy)benzenamine | HCID 11564798 | — |
| 반응물 | 5,8-Dibromoimidazo[1,2-a]pyrazine | HCID 53485949 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[4-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-amine | HCID 59023106 | — |
반응 단계
To a solution of 5,8-dibromo-imidazo[1,2-a]pyrazine (0.100 g, 0.36 mmol) in isopropanol (5 mL) are added 1,4-diazabicyclo[2,2,2]octane (DABCO) (0.036 mL, 0.36 mmol) and 4-(1-methyl-piperidin-4-ylmethoxy)-phenylamine (79.6 mg, 0.36 mmol). The reaction mixture is stirred at 90° C. overnight. The solvent is evaporated and the residue chromatographed on silica gel column eluting with 97:3 followed by 94:6 and 90:10 DCM:MeOH. The title compound is obtained as a solid (20 mg, 13%). LCMS: Rt 2.30 min (94%), m/z (APCI) 417.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08173656B2 |
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| 출처 데이터셋 | uspto-grants-2012_05 |
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| ORD ID | ord-e3b8de7b6dbb45e09e7c471d0220aa6e |
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| 출처 메모 | uspto-grants-2012_05 |
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