2-methyl-5-(4-nitrophenyl)-2H-tetrazole → 4-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)aniline

HRID 1921793노트

반응식

HRID 1921793 반응식
[CH3:1][N:2]1[N:6]=[N:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)=[N:3]1>[Pd].C(O)C>[CH3:1][N:2]1[N:6]=[N:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)=[N:3]1

참가 물질

4

반응물 1

HCID 3231922-methyl-5-(4-nitrophenyl)-2H-tetrazole

생성물 1

HCID 11328464-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)aniline수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 2-methyl-5-(4-nitro-phenyl)-2H-tetrazole (0.260 g, 1.27 mmol) and palladium on charcoal (53.6 mg) in ethanol (50 mL) is stirred in high pressure reactor under H2 at 4 bars for 17 hours. The catalyst is removed by filtration through Celite 521, washing with EtOH. The filtrates are combined and concentrated in vacuo to afford the title compound as a white solid (0.213 g, 96%). HPLC (254 nm) 1.50 min (89%)

후처리

  1. customThe catalyst is removed by filtration through Celite 521
  2. washwashing with EtOH
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-277e7eb90c854d81bdd6ff8fd2f6bb88
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173656B2

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