Tetrahydrofuran → (5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(3-hydroxymethyl-4-morpholin-4-yl-phenyl)-carbamic acid tert-butyl ester

HRID 1921850노트

반응식

HRID 1921850 반응식
[C:1]([O:5][C:6](=[O:39])[N:7]([C:29]1[C:30]2[N:31]([CH:36]=[CH:37][N:38]=2)[C:32]([Br:35])=[CH:33][N:34]=1)[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:10]([C:20](C)(C)[O:21][SiH2]C(C)(C)C)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C1COCC1>[F-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([O:5][C:6](=[O:39])[N:7]([C:29]1[C:30]2[N:31]([CH:36]=[CH:37][N:38]=2)[C:32]([Br:35])=[CH:33][N:34]=1)[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)=[C:10]([CH2:20][OH:21])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 8028TetrahydrofuranHCID 131728707(5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-morpholin-4-yl-phenyl]-carbamic acid tert-butyl ester

생성물 1

HCID 86652629(5-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(3-hydroxymethyl-4-morpholin-4-yl-phenyl)-carbamic acid tert-butyl ester

시약·촉매·용매 1

HCID 2724141Tetrabutylammonium Fluoride용매

실험 절차

A solution of (5-bromo-imidazo[1,2-a]pyrazin-8-yl)-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-morpholin-4-yl-phenyl]-carbamic acid tert-butyl ester (0.164 g, 0.265 mmol) in 1M tetrabutylammonium fluoride in THF (0.29 mL, 0.29 mmol) is stirred at room temperature overnight. The solvent is removed under vacuum and the residue is purified by silica gel column chromatography eluting with ethyl acetate. The title compound is isolated (0.126 g, 94%).

후처리

  1. customThe solvent is removed under vacuum
  2. customthe residue is purified by silica gel column chromatography
  3. washeluting with ethyl acetate

출처 및 근거

ORD 기록
ord-8df740308284487896e1e9f775dfbdeb
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173656B2

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