Tetrabutylammonium Fluoride → Methyl E4-[5-[2-(4-tert-butylbenzyloxy)phenyl]-3-(3,5-difluoro-4-hydroxybenzyl)pent-4-enyl]-benzoate

HRID 1921889노트

반응식

HRID 1921889 반응식
[C:1]([C:5]1[CH:53]=[CH:52][C:8]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2/[CH:17]=[CH:18]/[CH:19]([CH2:32][C:33]2[CH:38]=[C:37]([F:39])[C:36]([O:40][Si](C(C)C)(C(C)C)C(C)C)=[C:35]([F:51])[CH:34]=2)[CH2:20][CH2:21][C:22]2[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][CH:23]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2/[CH:17]=[CH:18]/[CH:19]([CH2:32][C:33]2[CH:38]=[C:37]([F:39])[C:36]([OH:40])=[C:35]([F:51])[CH:34]=2)[CH2:20][CH2:21][C:22]2[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][CH:23]=2)=[CH:52][CH:53]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 57971919HCID 57971919, 화합물

생성물 1

HCID 57971935Methyl E4-[5-[2-(4-tert-butylbenzyloxy)phenyl]-3-(3,5-difluoro-4-hydroxybenzyl)pent-4-enyl]-benzoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

780 mg (1.05 mmol) of methyl E-4-[5-[2-(4-tert-butylbenzyloxy)phenyl]-3-(3,5-difluoro-4-triisopropylsilanyloxybenzyl)pent-4-enyl]benzoate are introduced into 20 ml of THF at room temperature under argon, 2.11 ml (2.11 mmol) of a 1 M solution of tetra-n-butylammonium fluoride in THF are added, and the mixture is stirred at room temperature until reaction is complete. All the volatile components are then removed in vacuo. The resulting crude product is purified by preparative HPLC. 229 mg (37% of theory) of the title compound are obtained.

후처리

  1. customAll the volatile components are then removed in vacuo
  2. customThe resulting crude product is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-c67f009f71944fc298f713e35bb4652a
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173704B2

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