Hydrogen Peroxide → HCID 59536621, 화합물

HRID 1922174노트

반응식

HRID 1922174 반응식
[OH:1]O.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[C:7]([CH3:14])[N:6]=1.O>ClCCl>[CH3:3][O:4][C:5]1[N:6]=[C:7]([CH3:14])[C:8]([OH:1])=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 27630842-Methyl-6-methoxypyridine-3-boronic acid

생성물 1

HCID 59536621HCID 59536621, 화합물수율 62.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Add hydrogen peroxide (7.69 mL, 89.8 mmol) to a stirred mixture of 2-methoxy-6-methyl-5-pyridylboronic acid (5.0 g, 30 mmol) in dichloromethane (100 mL) kept under nitrogen at room temperature. Stir overnight at ambient temperature, add water and extract the mixture with dichloromethane. Combine the organic phases, dry (MgSO4), filter and concentrate to afford 2.6 g (62%) of the title compound. MS (m/z)=140 [M+1]

후처리

  1. customkept under nitrogen at room temperature
  2. extractionextract the mixture with dichloromethane
  3. dry with materialdry (MgSO4)
  4. filtrationfilter
  5. concentrationconcentrate

출처 및 근거

ORD 기록
ord-15719b56bbb1479dae037ccbf7d0d6db
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173821B2

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