tert-butyl (3S)-3-aminopiperidine-1-carboxylate → HCID 57725419, 화합물

HRID 1922226노트

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HRID 1922226 반응식
[CH3:1][NH:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:22]=[CH:21][C:14]3[N:15]=[C:16](S(C)=O)[S:17][C:13]=3[CH:12]=2)[CH:7]=[CH:6][N:5]=1.[NH2:24][C@H:25]1[CH2:30][CH2:29][CH2:28][N:27]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:26]1>CN1C(=O)CCC1>[CH3:1][NH:2][C:3]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:22]=[CH:21][C:14]3[N:15]=[C:16]([NH:24][C@H:25]4[CH2:30][CH2:29][CH2:28][N:27]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:26]4)[S:17][C:13]=3[CH:12]=2)[CH:7]=[CH:6][N:5]=1)=[O:23]

참가 물질

4

반응물 2

HCID 1501975tert-butyl (3S)-3-aminopiperidine-1-carboxylateHCID 577253932-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]-

생성물 1

HCID 57725419HCID 57725419, 화합물수율 40%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

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온도
105 °C

실험 절차

To the solution of N-methyl-4-(2-(methylsulfinyl)benzo[d]thiazol-6-yloxy)picolinamide (104 mg, 0.3 mmol) in 2 ml of NMP was added (S)-tert-butyl 3-aminopiperidine-1-carboxylate (240 mg, 1.2 mmol). The reaction solution was stirred at 105° C. for 5 days. The crude reaction solution was purified on prep HPLC and evaporated in vacuo to give (S)-tert-butyl 3-(6-(2-(methylcarbamoyl)pyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate (56 mg, 0.12 mmol) as white powder. ES/MS m/z 484.2 (MH+).

후처리

  1. customThe crude reaction solution
  2. customwas purified on prep HPLC
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-abeedf157010450c8191908f66a1ba02
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08173689B2

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