Trifluoroacetic acid → 2-Methyl-2-(piperazin-1-yl)propan-1-ol
반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([CH3:18])([CH3:17])[CH2:15][OH:16])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:18][C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)([CH3:17])[CH2:15][OH:16]참가 물질
4
실험 절차
To a solution of 4-(2-hydroxy-1,1-dimethylethyl)piperazine-1-carboxylic acid tert-butyl ester (110 mg, 0.43 mmol) in DCM (3 mL) was added TFA (1 mL) and the resulting mixture stirred for 3 h. The reaction mixture was loaded onto an Isolute® SCX-2 cartridge which was washed with MeOH/DCM and the product eluted with 2M NH3/MeOH affording the title compound as an off-white solid (62 mg, 91%). 1H NMR (CDCl3, 400 MHz): δ 3.32 (2H, s), 2.90 (5H, t, J=4.78 Hz), 2.38-2.13 (4H, m), 1.03 (6H, s)
후처리
- washwas washed with MeOH/DCM
- washthe product eluted with 2M NH3/MeOH affording the title compound as an off-white solid (62 mg, 91%)
출처 및 근거
- ORD 기록
- ord-a19c98a7912f436eaf6eeb76b7c2ef08
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08173650B2
반응 노트
불러오는 중…