Oxalyl chloride → Quinuclidin-4-ylcarbonyl chloride hydrochloride

HRID 1923397노트

반응식

HRID 1923397 반응식
[ClH:1].[N:2]12[CH2:9][CH2:8][C:5]([C:10](O)=[O:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2.C(Cl)(=O)C([Cl:16])=O>ClCCl.CN(C)C=O>[ClH:16].[N:2]12[CH2:9][CH2:8][C:5]([C:10]([Cl:1])=[O:11])([CH2:6][CH2:7]1)[CH2:4][CH2:3]2

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 667378251-Azabicyclo(2.2.2)octane-4-carboxylic acid hydrochloride

생성물 1

HCID 13760941Quinuclidin-4-ylcarbonyl chloride hydrochloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매2회

실험 절차

Quinuclidine-4-carboxylic acid hydrochloride (0.192 g, 0.001 mole) was suspended in dichloromethane (5 ml) and dimethylformamide (1 drop) and oxalyl chloride (0.436 ml. 0.635 g, 0.005 mole) were added. The resulting suspension was heated to reflux under an atmosphere of argon for six hours. Following concentration of the suspension in vacuo the residue was suspended in dichloromethane, concentrated in vacuo and finally dried in vacuo to give the title compound as a pale brown solid.

후처리

  1. temperatureThe resulting suspension was heated
  2. temperatureto reflux under an atmosphere of argon for six hours
  3. concentrationconcentrated in vacuo
  4. customfinally dried in vacuo

출처 및 근거

ORD 기록
ord-f8c36db196cd4f3cbec6c561bc16468e
출처 데이터셋
uspto-grants-2012_05
특허 번호
USRE043390E1

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